In May 2001 the Lama spoke to high school students in Portland, Oregon, at an "Educating the Heart Summit." As reported by the Seattle Times, The Dalai Lama said acts of violence should be remembered, and then forgiveness should be extended to the perpetrators. But if someone has a gun and is trying to kill you, he said, it would be reasonable to shoot back with your own gun. Not at the head, where a fatal wound might result. But at some other body part, such as a leg.
The Lama's thinking on defensive gun use has evolved since then, apparently, because now he's a center mass guy.
As a public service, here is the first Dalai Lama Tactical Tip: